Newly developed photon-cell interactive Monte Carlo (pciMC) simulation for non-invasive and continuous diagnosis of blood during extracorporeal circulation support

Daisuke Sakota; Setsuo Takatani

doi:10.1117/12.889327

2 June 2011 Newly developed photon-cell interactive Monte Carlo (pciMC) simulation for non-invasive and continuous diagnosis of blood during extracorporeal circulation support

Daisuke Sakota, Setsuo Takatani

Author Affiliations +

Proceedings Volume 8092, Medical Laser Applications and Laser-Tissue Interactions V; 80920Y (2011) https://doi.org/10.1117/12.889327
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

We have sought for non-invasive diagnosis of blood during the extracorporeal circulation support. To achieve the goal, we have newly developed a photon-cell interactive Monte Carlo (pciMC) model for optical propagation through blood. The pciMC actually describes the interaction of photons with 3-dimentional biconcave RBCs. The scattering is described by micro-scopical RBC boundary condition based on geometric optics. By using pciMC, we modeled the RBCs inside the extracorporeal circuit will be oriented by the blood flow. The RBCs' orientation was defined as their long axis being directed to the center of the circulation tube. Simultaneously the RBCs were allowed to randomly rotate about the long axis direction. As a result, as flow rate increased, the orientation rate increased and converged to approximately 22% at 0.5 L/min flow rate and above. And finally, by using this model, the pciMC non-invasively and absolutely predicted Hct and hemoglobin with the accuracies of 0.84±0.82 [HCT%] and 0.42±0.28 [g/dL] respectively against measurements by a blood gas analyzer.

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Daisuke Sakota and Setsuo Takatani "Newly developed photon-cell interactive Monte Carlo (pciMC) simulation for non-invasive and continuous diagnosis of blood during extracorporeal circulation support", Proc. SPIE 8092, Medical Laser Applications and Laser-Tissue Interactions V, 80920Y (2 June 2011); https://doi.org/10.1117/12.889327

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