8 June 2011 Study of light scattering and transparency in human edematous corneas and application to corneal grafts
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The optical properties of the cornea have been a research subject of great interest for many years. Several early theories have been put forward to explain with more or less success the optical transparency of this tissue, but it was not until Maurice demonstrated in a very elegant way during the 50s that this optical transparency could be explained by the regular ultrastructure of the cornea. When becoming edematous, the cornea's ultrastructure is perturbed and the tissue becomes a strongly scattering medium. With the emergence of ophthalmologic surgery by ultrashort pulse lasers in recent years, a regain of interest in the subject of corneal transparency arose. However, relatively little and no recent data of transparency spectra measurements covering a large wavelength range is available in the literature. The purpose of this study is to provide quantitative values for light scattering and its relation to the degree of edema by measuring the spectrum of transmitted light through corneas presenting different degrees of edema. This paper focus on the comparison of laboratory measurements published earlier with a new simple method we propose We also for eye banks to quantitatively measure the degree of transparency of corneal grafts by measuring the modulation transfer function of a Siemens star viewed through a corneal graft. Indeed, there is no current method to determine the transparency of corneal graft but the subjectivity of the laboratory technician or the ophthalmic surgeon.
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Tal Marciano, Donald Peyrot, Caroline Crotti, Fatima Alahyane, Laura Kowalczuk, Karsten Plamann, "Study of light scattering and transparency in human edematous corneas and application to corneal grafts", Proc. SPIE 8092, Medical Laser Applications and Laser-Tissue Interactions V, 809217 (8 June 2011); doi: 10.1117/12.889617; https://doi.org/10.1117/12.889617

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