20 September 2011 Digital holography and tissue dynamics spectroscopy: on the road to high-content drug discovery
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Abstract
Digital holography, Fourier optics and speckle are combined to enable a new direction in drug discovery. Optical coherence imaging (OCI) is a coherence-gated imaging approach that captures dynamic speckle from inside living tissue. The speckle temporal fluctuations arise from internal motions in the biological tissue, and the changes in these motions caused by applying drugs can be captured and quantified using tissue dynamics spectroscopy (TDS). A phenotypic profile of many reference drugs provides a training set that would help classify new compounds that may be candidates as new anti-cancer drugs.
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D. D. Nolte, D. D. Nolte, R. An, R. An, K. Jeong, K. Jeong, J. Turek, J. Turek, } "Digital holography and tissue dynamics spectroscopy: on the road to high-content drug discovery", Proc. SPIE 8122, Tribute to Joseph W. Goodman, 81220N (20 September 2011); doi: 10.1117/12.896618; https://doi.org/10.1117/12.896618
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