To date, the lack of light delivery mechanisms to the oral cavity remains a barrier to the treatment of oral cancer with
photodynamic therapy (PDT). The greatest impediment to medical practitioners is the current need to shield the normal
tissues of the oral cavity, a costly and time-consuming procedure. In this research, we present the design of illumination
devices to deliver light to the oral cavity for PDT, which will facilitate administration of PDT in the clinic. The goal for
such an illumination device, as indicated by our clinical collaborators at Roswell Park Cancer Institute in Buffalo, NY, is
to limit exposure of healthy tissue and produce an average irradiance of 100 mW/cm2 over the treatment field, with
spatial non-uniformities below 10%. Furthermore, the size of the device must be compact to allow use in the oral cavity.
Our research led to the design and fabrication of two devices producing spatial non-uniformities below 6% over a
treatment area of 0.25 cm2 by design. One device consisted of an appropriately-sized reflector, inspired by solar
concentrators, illuminated by a cylindrical diffusing fiber optimally located within the reflector; another was a solid
lightpipe with a combination of optimized tapered and straight components.