7 September 2011 Advanced optical design for DNA sequencing systems
Author Affiliations +
Recent advances in DNA sequencing techniques require the development of high NA immersion microscope systems with large field-of-view, increased resolution and very tight distortion correction. This paper discusses the optical design and tolerance analysis of a NA 1.0 immersion microscope system with a field of view over 1 mm, which is to be used for four-color fluorescence spectroscopy. The microscope system includes an immersion objective lens and four tube lenses, and is corrected for a wide wavelength range from 490 nm to 712 nm. We will discuss critical aspects of designing this kind of optical system, including special glass selection required for chromatic correction.
© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Kirill Sobolev, Kirill Sobolev, Adel Joobeur, Adel Joobeur, Craig Uhrich, Craig Uhrich, David Aziz, David Aziz, "Advanced optical design for DNA sequencing systems", Proc. SPIE 8128, Current Developments in Lens Design and Optical Engineering XII; and Advances in Thin Film Coatings VII, 812809 (7 September 2011); doi: 10.1117/12.894268; https://doi.org/10.1117/12.894268


Optical system design of descent camera
Proceedings of SPIE (December 08 2005)
A design method for quasi-symmetrical wide angle systems
Proceedings of SPIE (February 17 2004)
Optimization glitches in zoom lens design
Proceedings of SPIE (September 24 1997)
Recent Developments In High Speed Lens Design At The NPRL
Proceedings of SPIE (August 31 1987)

Back to Top