Snapshot Mueller polarimetry for biomedical diagnostic related to human liver fibrosis: evaluation of the method for biomedical assessments

P. Babilotte; M. Dubreuil; S. Rivet; Y. Lijour; D. Sevrain; L. Martin; G. Le Brun; Y. Le Grand; B. Le Jeune

doi:10.1117/12.896615

30 September 2011 Snapshot Mueller polarimetry for biomedical diagnostic related to human liver fibrosis: evaluation of the method for biomedical assessments

P. Babilotte, M. Dubreuil, S. Rivet, Y. Lijour, D. Sevrain, L. Martin, G. Le Brun, Y. Le Grand, B. Le Jeune

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Proceedings Volume 8172, Optical Complex Systems: OCS11; 817206 (2011) https://doi.org/10.1117/12.896615
Event: SPIE Optical Systems Design, 2011, Marseille, France

Abstract

Human liver biopsy samples, consisting into a 16 μm thickness biomaterial chemically fixed into a formaldehyde matrix, and stained by red picrosirius dye, are analysed for different states of fibrosis degeneration. Polarimetric methods, and specially Mueller polarimetry based on wavelength coding, have been qualified as an efficient tool to describe many different biological aspects. The polarimetric characteristics of the media, extracted from a Lu and Chipman decomposition^{1, 2} of their Mueller Matrix (MM), are correlated with the degeneracy level of tissue. Different works and results linked to the clinical analysis will be presented and compared to previous performed works.³ Polarimetric imaging will be presented and compared with SHG measurements. A statistical analysis of the distribution of polarimetric parameters (such as the retardance R and depolarisation P_d) will be presented too, in order to characterise the liver fibrosis level into the biomaterial under study.

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P. Babilotte, M. Dubreuil, S. Rivet, Y. Lijour, D. Sevrain, L. Martin, G. Le Brun, Y. Le Grand, and B. Le Jeune "Snapshot Mueller polarimetry for biomedical diagnostic related to human liver fibrosis: evaluation of the method for biomedical assessments", Proc. SPIE 8172, Optical Complex Systems: OCS11, 817206 (30 September 2011); https://doi.org/10.1117/12.896615

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