30 September 2011 Snapshot Mueller polarimetry for biomedical diagnostic related to human liver fibrosis: evaluation of the method for biomedical assessments
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Abstract
Human liver biopsy samples, consisting into a 16 μm thickness biomaterial chemically fixed into a formaldehyde matrix, and stained by red picrosirius dye, are analysed for different states of fibrosis degeneration. Polarimetric methods, and specially Mueller polarimetry based on wavelength coding, have been qualified as an efficient tool to describe many different biological aspects. The polarimetric characteristics of the media, extracted from a Lu and Chipman decomposition1, 2 of their Mueller Matrix (MM), are correlated with the degeneracy level of tissue. Different works and results linked to the clinical analysis will be presented and compared to previous performed works.3 Polarimetric imaging will be presented and compared with SHG measurements. A statistical analysis of the distribution of polarimetric parameters (such as the retardance R and depolarisation Pd) will be presented too, in order to characterise the liver fibrosis level into the biomaterial under study.
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P. Babilotte, P. Babilotte, M. Dubreuil, M. Dubreuil, S. Rivet, S. Rivet, Y. Lijour, Y. Lijour, D. Sevrain, D. Sevrain, L. Martin, L. Martin, G. Le Brun, G. Le Brun, Y. Le Grand, Y. Le Grand, B. Le Jeune, B. Le Jeune, } "Snapshot Mueller polarimetry for biomedical diagnostic related to human liver fibrosis: evaluation of the method for biomedical assessments", Proc. SPIE 8172, Optical Complex Systems: OCS11, 817206 (30 September 2011); doi: 10.1117/12.896615; https://doi.org/10.1117/12.896615
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