Human liver biopsy samples, consisting into a 16 μm thickness biomaterial chemically fixed into a formaldehyde
matrix, and stained by red picrosirius dye, are analysed for different states of fibrosis degeneration. Polarimetric
methods, and specially Mueller polarimetry based on wavelength coding, have been qualified as an efficient tool
to describe many different biological aspects. The polarimetric characteristics of the media, extracted from a Lu
and Chipman decomposition1, 2 of their Mueller Matrix (MM), are correlated with the degeneracy level of tissue.
Different works and results linked to the clinical analysis will be presented and compared to previous performed
works.3 Polarimetric imaging will be presented and compared with SHG measurements. A statistical analysis of
the distribution of polarimetric parameters (such as the retardance R and depolarisation Pd) will be presented
too, in order to characterise the liver fibrosis level into the biomaterial under study.