22 July 2011 Evanescent field absorption based photonic polymer waveguide biosensor
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Proceedings Volume 8173, Photonics 2010: Tenth International Conference on Fiber Optics and Photonics; 817304 (2011) https://doi.org/10.1117/12.897799
Event: International Conference on Fiber Optics and Photonics, 2010, Guwahati, India
Abstract
This paper details the design and fabrication of an integrated optical waveguide biosensor for antibody/antigen detection. SU-8 polymer is used as the core material to have a bi-conical tapered waveguide fabricated on a silicon substrate. PDMS is used as a buffer layer. The waist diameter of the biconical tapered waveguide has been optimized using Opti-BPM CAD software before fabrication. In addition, the fabrication technique employs simultaneous and single-step formation of the polymer waveguide structures for the guidance of light with V-grooves for low-cost passive alignment of glass optical fiber. The designed biosensor chip demonstrates sensing of FITC tagged goat anti human IgG (GaHIgG) and HIgG immobilized over the sensor surface was the bio receptor. The sensor uses the evanescent field that is present at the surface of the core for rapid and accurate sensing of antibody/antigen in the range of few micrograms per ml.
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Indrajit Boiragi, Roshan Makkar, Bikash Dev Choudhury, Soumyo Mukherji, K. Chalapathi, "Evanescent field absorption based photonic polymer waveguide biosensor", Proc. SPIE 8173, Photonics 2010: Tenth International Conference on Fiber Optics and Photonics, 817304 (22 July 2011); doi: 10.1117/12.897799; https://doi.org/10.1117/12.897799
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