23 August 2011 Quantification of tissue oxygenation levels using diffuse reflectance spectroscopy
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Proceedings Volume 8173, Photonics 2010: Tenth International Conference on Fiber Optics and Photonics; 817308 (2011) https://doi.org/10.1117/12.897811
Event: International Conference on Fiber Optics and Photonics, 2010, Guwahati, India
Abstract
Tumor growth is characterized by increased metabolic activity. The light absorption profile of hemoglobin in dysplastic tissue is different from a normal tissue. Neovascularization is a hallmark of many diseases and can serve as a predictive biomarker for the detection of cancers. Spectroscopic techniques can provide information about the metabolic and morphological changes related to the progression of neoplasia. Diffuse reflectance spectroscopy (DRS) measures the absorption and scattering properties of a biological tissue and this method can provide clinically useful information for the early diagnosis of epithelial precancers. We used tissue simulating phantoms with absorbing and scattering molecules for the determination of total hemoglobin concentration, hemoglobin oxygen saturation and intensity difference between the deoxy and oxy hemoglobin bands. The results show promising approach for the differentiating normal and malignant states of a tissue.
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Suresh Anand B. S., Suresh Anand B. S., Sujatha N., Sujatha N., } "Quantification of tissue oxygenation levels using diffuse reflectance spectroscopy", Proc. SPIE 8173, Photonics 2010: Tenth International Conference on Fiber Optics and Photonics, 817308 (23 August 2011); doi: 10.1117/12.897811; https://doi.org/10.1117/12.897811
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