Identification of chemical warfare agents using a portable microchip-based detection device

K. Petkovic-Duran; A. Swallow; B. A. Sexton; F. Glenn; Y. Zhu

doi:10.1117/12.903211

23 December 2011 Identification of chemical warfare agents using a portable microchip-based detection device

K. Petkovic-Duran, A. Swallow, B. A. Sexton, F. Glenn, Y. Zhu

Proceedings Volume 8204, Smart Nano-Micro Materials and Devices; 82041L (2011) https://doi.org/10.1117/12.903211
Event: SPIE Smart Nano + Micro Materials and Devices, 2011, Melbourne, Australia

Abstract

Analysis of chemical warfare agents (CWAs) and their degradation products is an important verification component in support of the Chemical Weapons Convention and urgently demanding rapid and reliable analytical methods. A portable microchip electrophoresis (ME) device with contactless conductivity (CCD) detection was developed for the in situ identification of CWA and their degradation products. A 10mM MES/His, 0.4mM CTAB - based separation electrolyte accomplished the analysis of Sarin (GB), Tabun( GA) and Soman (GD) in less than 1 min, which is the fastest screening of nerve agents achieved with portable ME and CCD based detection methods to date. Reproducibility of detection was successfully demonstrated on simultaneous detection of GB (200ppm) and GA (278ppm). Reasonable agreement for the four consecutive runs was achieved with the mean peak time for Sarin of 29.15s, and the standard error of 0.58s or 2%. GD and GA were simultaneously detected with their degradation products methylphosphonic acid (MPA), pinacolyl methylphosphonic acid (PMPA) and O-Ethyl Phosphorocyanidate (GAHP and GAHP1) respectively. The detection limit for Sarin was around 35ppb. To the best of our knowledge this is the best result achieved in microchip electrophoresis and contactless conductivity based detection to date.

Citation Download Citation

K. Petkovic-Duran, A. Swallow, B. A. Sexton, F. Glenn, and Y. Zhu "Identification of chemical warfare agents using a portable microchip-based detection device", Proc. SPIE 8204, Smart Nano-Micro Materials and Devices, 82041L (23 December 2011); https://doi.org/10.1117/12.903211

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KEYWORDS

Charge-coupled devices

Nerve agents

Ultraviolet radiation

Chemical analysis

Sensors

CCD image sensors

Ultraviolet detectors

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