9 February 2012 Neuron absorption study and mid-IR optical excitations
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Abstract
Neuronal optical excitation can provide non-contacting tools to explore brain circuitry and a durable stimulation interface for cardiac pacing and visual as well as auditory sensory neuronal stimulation. To obtain accurate absorption spectra, we scan the transmission of neurons in cell culture medium, and normalize it by subtracting out the absorption spectrum of the medium alone. The resulting spectra show that the main neuronal absorption peaks are in the 3000- 6000nm band, although there is a smaller peak near 1450nm. By coupling the output of a 3μm interband cascade laser (ICL) into a mid-IR fluorozirconate fiber, we can effectively deliver more than 1J/cm2 photon intensity to the excitation site for neuronal stimulation.
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Dingkai Guo, Dingkai Guo, Xing Chen, Xing Chen, Shilpa Vadala, Shilpa Vadala, Jennie Leach, Jennie Leach, Yordan Kostov, Yordan Kostov, William W. Bewley, William W. Bewley, Chul-Soo Kim, Chul-Soo Kim, Mijin Kim, Mijin Kim, Chadwick L. Canedy, Chadwick L. Canedy, Charles D. Merritt, Charles D. Merritt, Igor Vurgaftman, Igor Vurgaftman, Jerry R. Meyer, Jerry R. Meyer, Fow-Sen Choa, Fow-Sen Choa, "Neuron absorption study and mid-IR optical excitations", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82075O (9 February 2012); doi: 10.1117/12.909561; https://doi.org/10.1117/12.909561
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