Intense high-frequency pressure waves produced with low laser fluences

Carlos Serpa; Gonçalo F. F. Sá; Luis G. Arnaut

doi:10.1117/12.908422

9 February 2012 Intense high-frequency pressure waves produced with low laser fluences

Carlos Serpa, Gonçalo F. F. Sá, Luis G. Arnaut

Proceedings Volume 8207, Photonic Therapeutics and Diagnostics VIII; 82070I (2012) https://doi.org/10.1117/12.908422
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Pressure waves generated by laser pulses can permeabilize biological barriers, such as the skin or cellular membranes. The characteristics of the absorbing materials are decisive in determining the shape and amplitude of pressure impulse transients. Based on the physics and photochemistry of light-to-pressure conversion, we generate high intensity broadband ultrasound capable of transiently permeabilizing biological barriers. We show evidence that no damage is done to cells exposed to such pressure waves and that skin recovers its protective function some minutes after exposure to the pressure waves. The ability of the pressure waves to promote transient skin permeabilization is assessed by the increase of transepidermal water loss (TEWL) immediately after the application of pressure waves, and by the full recovery of the skin to the normal TEWL values in the following minutes.

Citation Download Citation

Carlos Serpa, Gonçalo F. F. Sá, and Luis G. Arnaut "Intense high-frequency pressure waves produced with low laser fluences", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82070I (9 February 2012); https://doi.org/10.1117/12.908422

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available