9 February 2012 The in-vivo monitoring method for traumatic brain injury of mouse based on near-infrared light intensity
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Abstract
A system based on near-infrared light intensity was used to monitor mouse model of traumatic brain injury (TBI) noninvasively. The measurement system was controlled by microcontroller. Light from a 760/850nm dual-wavelength light emitting diode was coupled to a 0.6-mm-diameter optical fiber. The collection fibers were coupled to optoelectronic detectors, which were placed in the different distance from the source fiber. The system consisted of a constant current bias, a circuit lock-in amplifier (including band pass filter, lock-in amplifier, and low pass filter), a PCI 6240 data acquisition card and a multi-core-processor computer. The modified Lambert Beer law was used to calculate the concentration of ΔHbO2 and ΔHb. The sensitivity matrix was defined to evaluate the region of effective detection of optical probe. Five groups of TBI mouse models were built by Feeney's free-falling method. The data measured by system show after TBI the concentration of ΔHbO2 decreased and that of ΔHb increased. It can be concluded that the system can be used to monitor the changes of TBI of mouse non-invasively.
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Weitao Li, Weitao Li, Xuena Wang, Xuena Wang, Zhiyu Qian, Zhiyu Qian, Jieru Xie, Jieru Xie, Xing Liu, Xing Liu, } "The in-vivo monitoring method for traumatic brain injury of mouse based on near-infrared light intensity", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82071N (9 February 2012); doi: 10.1117/12.903859; https://doi.org/10.1117/12.903859
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