9 February 2012 Improvements to a laser Raman spectroscopy system for reducing the false positives of autofluorescence bronchoscopies
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Preneoplastic lesions of the bronchial tree have a high probability of developing into malignant tumours. Currently the best method for localizing them for further treatment is a combined white light and autofluorescence bronchoscopy (WLB+AFB). Unfortunately the average specificity from large clinical trials for this combined detection method is low at around 60%, which can result in many false positives. However a recent pilot study showed that adding a point laser Raman spectroscopy (LRS) measurement improved the specificity of detecting lesions with high grade dysplasia or carcinoma in situ to 91% with a sensitivity of 96% compared to WLB+AFB alone. Despite this success, there is still room for much improvement. One constant need is to find better ways to measure the inherently weak Raman emissions in vivo which will result in even better diagnostic sensitivity and specificity. With this aim in mind a new generation Raman system was developed. The system uses the latest charge coupled device (CCD) with low noise, and fast cool down times. A spectrometer was incorporated that was able to measure both the low and high frequency Raman emissions with high resolution. The Raman catheter was also redesigned to include a visible light channel to facilitate the accurate indication of the area being measured. Here the benefits in the adjunct use of LRS to WLB + AFB are presented, and description of the new system and the improvements it offers over the old system are shown.
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Hanna C. Pawluk, Hanna C. Pawluk, Michael A. Short, Michael A. Short, Stephen Lam, Stephen Lam, Annette M. McWilliams, Annette M. McWilliams, Diana N. Ionescue, Diana N. Ionescue, Haishan Zeng, Haishan Zeng, } "Improvements to a laser Raman spectroscopy system for reducing the false positives of autofluorescence bronchoscopies", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 820737 (9 February 2012); doi: 10.1117/12.908739; https://doi.org/10.1117/12.908739

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