9 February 2012 Laser-driven short-duration heating angioplasty: chronic artery lumen patency and histology in porcine iliac artery
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Abstract
We proposed a short-duration heating balloon angioplasty. We designed a prototype short-duration heating balloon catheter that can heat artery media to 60-70°C within 15-25 s with a combination of laser-driven heat generation and continuous fluid irrigation in the balloon. The purpose of this study was to investigate chronic artery lumen patency as well as histological alteration of artery wall after the short-duration heating balloon dilatation with porcine healthy iliac artery. The short-term heating balloon dilated sites were angiographically patent in acute (1 hour) and in chronic phases (1 and 4 weeks). One week after the dilatation, smooth muscle cells (SMCs) density in the artery media measured from H&E-stained specimens was approx. 20% lower than that in the reference artery. One and four weeks after the dilatations, normal structure of artery adventitia was maintained without any incidence of thermal injury. Normal lamellar structure of the artery media was also maintained. We found that the localized heating restricted to artery media by the short-duration heating could maintain adventitial function and artery normal structure in chronic phase.
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Natsumi Shimazaki, Natsumi Shimazaki, Mie Kunio, Mie Kunio, Sho Naruse, Sho Naruse, Tsunenori Arai, Tsunenori Arai, Masami Sakurada, Masami Sakurada, } "Laser-driven short-duration heating angioplasty: chronic artery lumen patency and histology in porcine iliac artery", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82074F (9 February 2012); doi: 10.1117/12.909870; https://doi.org/10.1117/12.909870
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