9 February 2012 Contrast-enhanced diffuse optical tomography of brain perfusion in humans using ICG
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Regular monitoring of brain perfusion at the bedside in neurointensive care is desirable. Currently used imaging modalities are not suited for constant monitoring and often require a transport of the patient. Noninvasive near infrared spectroscopy (NIRS) in combination with an injection of a safe dye (indocyanine green, ICG) could serve as a quasi-continuous brain perfusion monitor. In this work, we evaluate prerequisites for the development of a brain perfusion monitor using continuous wave (cw) NIRS technique. We present results from a high-resolution diffuse optical tomography (HR-DOT) experiment in humans demonstrating the separation of signals from skin from the brain. This technique can help to monitor neurointensive care patients on a regular basis, detecting changes in cortical perfusion in time.
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Christina Habermehl, Christina Habermehl, Christoph Schmitz, Christoph Schmitz, Jens Steinbrink, Jens Steinbrink, "Contrast-enhanced diffuse optical tomography of brain perfusion in humans using ICG", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82074O (9 February 2012); doi: 10.1117/12.905742; https://doi.org/10.1117/12.905742

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