9 March 2012 Quantitative RNFL attenuation coefficient measurements by RPE-normalized OCT data
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Proceedings Volume 8209, Ophthalmic Technologies XXII; 82090U (2012) https://doi.org/10.1117/12.907764
Event: SPIE BiOS, 2012, San Francisco, California, United States
We demonstrate significantly different scattering coefficients of the retinal nerve fiber layer (RNFL) between normal and glaucoma subjects. In clinical care, SD-OCT is routinely used to assess the RNFL thickness for glaucoma management. In this way, the full OCT data set is conveniently reduced to an easy to interpret output, matching results from older (non- OCT) instruments. However, OCT provides more data, such as the signal strength itself, which is due to backscattering in the retinal layers. For quantitative analysis, this signal should be normalized to adjust for local differences in the intensity of the beam that reaches the retina. In this paper, we introduce a model that relates the OCT signal to the attenuation coefficient of the tissue. The average RNFL signal (within an A-line) was then normalized based on the observed RPE signal, resulting in normalized RNFL attenuation coefficient maps. These maps showed local defects matching those found in thickness data. The average (normalized) RNFL attenuation coefficient of a fixed band around the optic nerve head was significantly lower in glaucomatous eyes than in normal eyes (3.0mm-1 vs. 4.9mm-1, P<0.01, Mann-Whitney test).
© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
K. A. Vermeer, K. A. Vermeer, J. van der Schoot, J. van der Schoot, H. G. Lemij, H. G. Lemij, J. F. de Boer, J. F. de Boer, } "Quantitative RNFL attenuation coefficient measurements by RPE-normalized OCT data", Proc. SPIE 8209, Ophthalmic Technologies XXII, 82090U (9 March 2012); doi: 10.1117/12.907764; https://doi.org/10.1117/12.907764


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