9 March 2012 Corneal tissue ablation using 6.1 μm quantum cascade laser
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Proceedings Volume 8209, Ophthalmic Technologies XXII; 82091W (2012) https://doi.org/10.1117/12.908468
Event: SPIE BiOS, 2012, San Francisco, California, United States
Abstract
High absorption property of tissues in the IR range (λ> 2 μm) results in effective tissue ablation, especially near 3 μm. In the mid-infrared range, wavelengths of 6.1 μm and 6.45 μm fall into the absorption bands of the amide protein groups Amide-I and Amide-II, respectively. They also coincide with the deformation mode of water, which has an absorption peak at 6.1 μm. This coincidence makes 6.1 μm laser a better ablation tool that has promising effectiveness and minimum collateral damages than 3 μm lasers. In this work, we performed bovine corneal ablation test in-vitro using high-power 6.1μm quantum cascade laser (QCL) operated at pulse mode. Quantum cascade laser has the advantages of low cost, compact size and tunable wavelength, which makes it great alternative Mid-IR light source to conventional tunable free-electron lasers (FEL) for medical applications. Preliminary results show that effective corneal stroma craters were achieved with much less collateral damage in corneal tissue that contains less water. Future study will focus on optimizing the control parameters of QCL to attain neat and precise ablation of corneal tissue and development of high peak power QCL.
© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Yong Huang, Jin U. Kang, "Corneal tissue ablation using 6.1 μm quantum cascade laser", Proc. SPIE 8209, Ophthalmic Technologies XXII, 82091W (9 March 2012); doi: 10.1117/12.908468; https://doi.org/10.1117/12.908468
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