13 February 2012 A compact fluorescence and white light imaging system for intraoperative visualization of nerves
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Abstract
Fluorescence image guided surgery (FIGS) allows intraoperative visualization of critical structures, with applications spanning neurology, cardiology and oncology. An unmet clinical need is prevention of iatrogenic nerve damage, a major cause of post-surgical morbidity. Here we describe the advancement of FIGS imaging hardware, coupled with a custom nerve-labeling fluorophore (GE3082), to bring FIGS nerve imaging closer to clinical translation. The instrument is comprised of a 405nm laser and a white light LED source for excitation and illumination. A single 90 gram color CCD camera is coupled to a 10mm surgical laparoscope for image acquisition. Synchronization of the light source and camera allows for simultaneous visualization of reflected white light and fluorescence using only a single camera. The imaging hardware and contrast agent were evaluated in rats during in situ surgical procedures.
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Dan Gray, Evgenia Kim, Victoria Cotero, Paul Staudinger, Siavash Yazdanfar, Cristina Tan Hehir, "A compact fluorescence and white light imaging system for intraoperative visualization of nerves", Proc. SPIE 8214, Advanced Biomedical and Clinical Diagnostic Systems X, 821402 (13 February 2012); doi: 10.1117/12.905757; https://doi.org/10.1117/12.905757
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