22 February 2012 Diffuse reflectance spectral imaging for breast tumor margin assessment
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Diffuse reflectance spectroscopy has been previously explored as a promising method for providing real-time visual maps of tissue composition to help surgeons determine breast lumpectomy margins and to ensure the complete removal of a tumor during surgery. We present the simple design, validation, and implementation of a compact and cost-effective spectral imaging system for the application of tumor margin assessment. Our new system consists of a broadband source with bandpass filters for illumination and a fabricated custom 16-pixel photodiode imaging array for the detection of diffuse reflectance. The system prototype was characterized in tissue-mimicking phantoms and has an SNR of greater than 40 dB in phantoms, animals, and human tissue. We show proof-of-concept for performing fast, wide-field spectral imaging with a simple, inexpensive design. The strategy also allows for the scaling to higher pixel number and density in future iterations of the system.
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Justin Y. Lo, Sulochana Dhar, Bing Yu, Martin A. Brooke, Thomas F. Kuech, Nan M. Jokerst, Nimmi Ramanujam, "Diffuse reflectance spectral imaging for breast tumor margin assessment", Proc. SPIE 8214, Advanced Biomedical and Clinical Diagnostic Systems X, 821407 (22 February 2012); doi: 10.1117/12.909259; https://doi.org/10.1117/12.909259

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