Translator Disclaimer
Paper
28 February 2012 Strip mosaicing confocal microscopy for rapid imaging over large areas of excised tissue
Author Affiliations +
Abstract
Confocal mosaicing microscopy is a developing technology platform for imaging tumor margins directly in fresh tissue, without the processing that is required for conventional pathology. Previously, basal cell carcinoma margins were detected by mosaicing of confocal images of 12 x 12 mm2 of excised tissue from Mohs surgery. This mosaicing took 9 minutes. Recently we reported the initial feasibility of a faster approach called "strip mosaicing" on 10 x 10 mm2 of tissue that was demonstrated in 3 minutes. In this paper we report further advances in instrumentation and software. Rapid mosaicing of confocal images on large areas of fresh tissue potentially offers a means to perform pathology at the bedside. Thus, strip mosaicing confocal microscopy may serve as an adjunct to pathology for imaging tumor margins to guide surgery.
© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Sanjee Abeytunge, Yongbiao Li, Bjorg Larson, Gary Peterson, Ricardo Toledo-Crow, and Milind Rajadhyaksha "Strip mosaicing confocal microscopy for rapid imaging over large areas of excised tissue", Proc. SPIE 8214, Advanced Biomedical and Clinical Diagnostic Systems X, 821412 (28 February 2012); https://doi.org/10.1117/12.909416
PROCEEDINGS
16 PAGES


SHARE
Advertisement
Advertisement
Back to Top