Instrumentation considerations for measurement of early arriving photons in diffuse optical tomography

Niksa Valim; Mark Niedre

doi:10.1117/12.908774

28 February 2012 Instrumentation considerations for measurement of early arriving photons in diffuse optical tomography

Niksa Valim, Mark Niedre

Proceedings Volume 8215, Design and Quality for Biomedical Technologies V; 82150K (2012) https://doi.org/10.1117/12.908774
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Time-resolved measurement of early-arriving photons has been shown by a number of groups to effectively reduce photon scatter and improve resolution in diffuse optical tomography (DOT) and fluorescence mediated tomography (FMT). Recently, we experimentally showed that measurement of early-arriving photons resulted in the reduction of the instrument photon density sensitivity function (PDSF) width by a factor of 2 to 2.5 over a wide range of relevant small-animal imaging conditions using a picosecond pulsed laser and time-resolved photon counting combination. However, we also showed that this experimental improvement was less than predicted from time-resolved Monte Carlo simulations. Specifically, a reduction by a factor of 4 or better was predicted, but this could not be achieved with our system. To better understand this, in this work we have experimentally tested the effect of a series instrumentation (hardware) parameters on the experimentally measured time-dependant PDSFs including, i) source and detector geometry, ii) detector sensitivity, iii) laser illumination intensity, and iv) instrument temporal impulse response function. Our ongoing research indicates that all of these parameters affected the relative PDSF width by as much as 10-25%, particularly at early time points. The results of this work are significant because they show in a number of cases that significant disagreement between experimental PDSFs and theoretical models exist as a result of minor changes in experimental configuration. We also anticipate that these results will be useful in the design of future time-resolved DOT and DFT imaging systems.

Citation Download Citation

Niksa Valim and Mark Niedre "Instrumentation considerations for measurement of early arriving photons in diffuse optical tomography", Proc. SPIE 8215, Design and Quality for Biomedical Technologies V, 82150K (28 February 2012); https://doi.org/10.1117/12.908774

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