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1 March 2012 Development of a widefield SERS imaging endoscope
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Proceedings Volume 8217, Endoscopic Microscopy VII; 821704 (2012)
Event: SPIE BiOS, 2012, San Francisco, California, United States
We report on the design and testing of a prototype widefield surface enhanced Raman scattering (SERS) imaging system based on a fiber optic bronchoscope using bandpass filters for Raman signal selection. The SERS contrast agents employed consist of gold nanoparticles encoded with a Raman-active dye and made specific for lung adenocarcinoma tissue through the use of an anti-epidermal growth factor receptor (EGFR) antibody. By exploiting the extremely narrow SERS spectral peaks we demonstrate a facile method of background fluorescence rejection that can be implemented at sub-video rates. The system has been tested on in-vivo tissues and performance metrics, including the maximum tissue penetration and minimum detectable nanoparticle quantity have been determined in a standardized fashion.
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Patrick Z. McVeigh, Rupananda J. Mallia, Israel Veilleux, and Brian C. Wilson "Development of a widefield SERS imaging endoscope", Proc. SPIE 8217, Endoscopic Microscopy VII, 821704 (1 March 2012);

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