30 January 2012 Label-free DNA biosensor based on doubled tilted fiber Bragg grating
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The realization of a DNA biosensor based on Double Tilted Fiber Bragg Grating (DTFBG) for label-free detection has been demonstrated. To our knowledge this is the first time that a biosensor has been realized with such kind of device. The surface of the optical fiber has been functionalized with peptide nucleic acid (PNA) in order to capture DNA strands. The changes of the interference fringes visibility of the grating, due to the PNA-DNA binding, proved the occurred fiber hybridization. The re-use of the fiber for multiple measurements and the selectivity of the sensor have been also investigated.
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Alessandro Candiani, Alessandro Candiani, Michele Sozzi, Michele Sozzi, Annamaria Cucinotta, Annamaria Cucinotta, Stefano Selleri, Stefano Selleri, Rosanna Veneziano, Rosanna Veneziano, Roberto Corradini, Roberto Corradini, Rosangela Marchelli, Rosangela Marchelli, Paul Childs, Paul Childs, Stavros Pissadakis, Stavros Pissadakis, } "Label-free DNA biosensor based on doubled tilted fiber Bragg grating", Proc. SPIE 8218, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XII, 82180N (30 January 2012); doi: 10.1117/12.908100; https://doi.org/10.1117/12.908100

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