Preclinical evaluation of a Raman spectroscopic probe for endoscopic classification of oesophageal pathologies

L. M. Almond; J. Hutchings; G. R. Lloyd; J. Francis-Jones; N. Stone; H. Barr; C. Kendall

doi:10.1117/12.919876

31 January 2012 Preclinical evaluation of a Raman spectroscopic probe for endoscopic classification of oesophageal pathologies

L. M. Almond, J. Hutchings, G. R. Lloyd, J. Francis-Jones, N. Stone, H. Barr, C. Kendall

Author Affiliations +

Proceedings Volume 8219, Biomedical Vibrational Spectroscopy V: Advances in Research and Industry; 82190L (2012) https://doi.org/10.1117/12.919876
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Raman spectroscopy is an inelastic scattering technique capable of probing the biochemical changes associated with neoplastic progression in oesophageal tissue. Custom-built fibre-optic Raman probes could potentially provide opportunities for in vivo endoscopic diagnosis of pre-cancerous oesophageal lesions and targeted early therapy. However, prior to commencing a clinical trial convincing ex vivo work must demonstrate multi-operator, multi-centre and multi-system reliability. We report spectral consistency between two operators who independently evaluated two optically identical probes ex vivo. In addition, we demonstrate compatibility with high-definition white light endoscopes and narrow band imaging systems highlighting the potential for future endoscopic multi-modality imaging in the oesophagus.

Citation Download Citation

L. M. Almond, J. Hutchings, G. R. Lloyd, J. Francis-Jones, N. Stone, H. Barr, and C. Kendall "Preclinical evaluation of a Raman spectroscopic probe for endoscopic classification of oesophageal pathologies", Proc. SPIE 8219, Biomedical Vibrational Spectroscopy V: Advances in Research and Industry, 82190L (31 January 2012); https://doi.org/10.1117/12.919876

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