Angle-resolved spectroscopy: a tissue-mimicking phantom study

Yan Zhang; Fartash Vasefi; Astrid Chamson-Reig; Mohamadreza Najiminainia; Bozena Kaminska; Jeffrey J. L. Carson

doi:10.1117/12.909785

6 March 2012 Angle-resolved spectroscopy: a tissue-mimicking phantom study

Yan Zhang, Fartash Vasefi, Astrid Chamson-Reig, Mohamadreza Najiminainia, Bozena Kaminska, Jeffrey J. L. Carson

Proceedings Volume 8221, Optical Interactions with Tissue and Cells XXIII; 82211B (2012) https://doi.org/10.1117/12.909785
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

The Radial Angular Filter Array (RAFA) is a novel optical filter consisting of a radially-distributed series of micromachined channels with a focal length of a few millimeters. The RAFA filters photons passing through the focal point according to the propagation direction and has proven to be capable of collecting the angular distribution and the spectral information of photons simultaneously and non-invasively, which allows angle-resolved spectroscopic measurement of a turbid medium. To explore the feasibility of using this device to characterize the optical abnormalities in human tissues, we tested the performance of an angle-resolved RAFA-based spectroscopy system to detect absorption targets embedded within a tissue-mimicking phantom. The body of the phantom was made of 0.1% Intralipid^TM/agarose gel (7 mm in thickness) and the targets were spherical (1.5 mm in radius) and contained 10 μM Indocyanine Green (ICG). The illumination source was a broadband near infrared (NIR) collimated beam. Photons were angularly filtered by the RAFA and spectrally resolved by a pushbroom spectrometer. The experimental results confirmed that the RAFA preferentially filtered photons that carried absorption and scattering information of the embedded targets.

Citation Download Citation

Yan Zhang, Fartash Vasefi, Astrid Chamson-Reig, Mohamadreza Najiminainia, Bozena Kaminska, and Jeffrey J. L. Carson "Angle-resolved spectroscopy: a tissue-mimicking phantom study", Proc. SPIE 8221, Optical Interactions with Tissue and Cells XXIII, 82211B (6 March 2012); https://doi.org/10.1117/12.909785

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