9 February 2012 Investigation on how to choose measurement sites for non-invasive near-infrared blood glucose sensing
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With the changing of human diet and the future of an aging society, the number of diabetic patients is growing rapidly and steadily. The major therapeutic method to that disease is monitoring the blood glucose concentration frequently to adjust the dose of the drugs and insulin. In order to avoid the painful finger prick, we choose the ear lobe as a measurement site with finger as a reference. Firstly, we compare the blood glucose concentration results of ear lobe and finger during an oral glucose tolerance test, the results showed a good correlation of the two sites. Secondly, the three-layered skin structure of finger and ear lobe has been studied by using optical coherence tomography (OCT) technique. The result shows that the thickness of each layer at ear lobe is thinner. Finally, the difference between reflectance spectra of finger and ear lobe is compared due to the diverse skin thickness. The results still show a higher absorbance value for ear lobe. In conclusion, the ear lobe is an ideal measurement site for noninvasive blood glucose sensing.
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Jingying Jiang, Jingying Jiang, Da Zou, Da Zou, Xiaolin Min, Xiaolin Min, Zhenhe Ma, Zhenhe Ma, Kexin Xu, Kexin Xu, } "Investigation on how to choose measurement sites for non-invasive near-infrared blood glucose sensing", Proc. SPIE 8222, Dynamics and Fluctuations in Biomedical Photonics IX, 822216 (9 February 2012); doi: 10.1117/12.905944; https://doi.org/10.1117/12.905944

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