23 February 2012 Optoacoustic angiography of peripheral vasculature
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We developed a new optoacoustic microangiography system (OmAS) intended for in-vivo vascular imaging of a human finger. The system employs an arc-shaped acoustic array that is rotated 360 degrees around the finger providing optoacoustic data necessary for tomographic reconstruction of the three-dimensional images of a finger. A near-infrared Q-switched laser is used to generate optoacoustic signals with increased contrast of blood vessels. The laser is coupled through two randomized fiberoptic bundles oriented in orthogonal optoacoustic mode. To demonstrate OmAS capabilities, we present a time-series of optoacoustic images of a human finger taken after the hypothermia stress test. The images show a detailed vascular anatomy of a finger down to the capillary level. A series of quick 30s scans allowed us to visualize the thermoregulatory response within the studied finger as it was manifested via vasomotor activity during the hypothermia recovery. We propose that the developed system can be used for diagnostics of various medical conditions that are manifested in change of the peripheral (finger) blood flow. Examples of the medical conditions that could be diagnosed and staged using the OmAS include the peripheral arterial disease (PAD), thrombosis, frostbite, and traumas.
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Sergey Ermilov, Sergey Ermilov, Richard Su, Richard Su, Mario Zamora, Mario Zamora, Travis Hernandez, Travis Hernandez, Vyacheslav Nadvoretsky, Vyacheslav Nadvoretsky, Alexander Oraevsky, Alexander Oraevsky, } "Optoacoustic angiography of peripheral vasculature", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82230D (23 February 2012); doi: 10.1117/12.911629; https://doi.org/10.1117/12.911629

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