In vivo photoacoustic tomography of total blood flow and Doppler angle

Junjie Yao; Konstantin I. Maslov; Lihong V. Wang

doi:10.1117/12.909480

23 February 2012 In vivo photoacoustic tomography of total blood flow and Doppler angle

Junjie Yao, Konstantin I. Maslov, Lihong V. Wang

Proceedings Volume 8223, Photons Plus Ultrasound: Imaging and Sensing 2012; 82230U (2012) https://doi.org/10.1117/12.909480
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

As two hallmarks of cancer, angiogenesis and hypermetabolism are closely related to increased blood flow. Volumetric blood flow measurement is important to understanding the tumor microenvironment and developing new means to treat cancer. Current photoacoustic blood flow estimation methods focus on either the axial or transverse component of the flow vector. Here, we propose a method to compute the total flow speed and Doppler angle by combining the axial and transverse flow measurements. Both the components are measured in M-mode. Collating the A-lines side by side yields a 2D matrix. The columns are Hilbert transformed to compare the phases for the computation of the axial flow. The rows are Fourier transformed to quantify the bandwidth for the computation of the transverse flow. From the axial and transverse flow components, the total flow speed and Doppler angle can be derived. The method has been verified by flowing bovine blood in a plastic tube at various speeds from 0 to 7.5 mm/s and at Doppler angles from 30 to 330°. The measurement error for total flow speed was experimentally determined to be less than 0.3 mm/s; for the Doppler angle, it was less than 15°. In addition, the method was tested in vivo on a mouse ear. The advantage of this method is simplicity: No system modification or additional data acquisition is required to use our existing system. We believe that the proposed method has the potential to be used for cancer angiogenesis and hypermetabolism imaging.

Citation Download Citation

Junjie Yao, Konstantin I. Maslov, and Lihong V. Wang "In vivo photoacoustic tomography of total blood flow and Doppler angle", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82230U (23 February 2012); https://doi.org/10.1117/12.909480

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Doppler tomography

Blood circulation

Doppler effect

In vivo imaging

Veins

Cancer

Acoustics

Show All Keywords

Keywords/Phrases

Search In:

Publication Years