23 February 2012 Drug delivery monitoring by photoacoustic tomography with an ICG encapsulated double emulsion
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Abstract
We successfully encapsulated ICG in an ultrasound-triggerable perfluorocarbon double emulsion that prevents ICG from binding with plasma proteins. Photoacoustic spectral measurements on point target as well as 2-D photoacoustic images of blood vessels revealed that the photoacoustic spectrum changes significantly in blood when the ICG-loaded emulsion undergoes acoustic droplet vaporization (ADV), which is the conversion of liquid droplets into gas bubbles using ultrasound. Other than providing a new photoacoustic contrast agent, the ICG encapsulated double emulsion, when imaged with photoacoustic tomography, could facilitate spatial and quantitative monitoring of ultrasound initiated drug delivery.
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Xueding Wang, Justin R. Rajian, Mario L. Fabiilli, J. Brian Fowlkes, and Paul L. Carson "Drug delivery monitoring by photoacoustic tomography with an ICG encapsulated double emulsion", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82232K (23 February 2012); doi: 10.1117/12.906452; https://doi.org/10.1117/12.906452
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