Synthesis and characterization of NIR light-responsive LbL nanocapsules

Xue-mei Chi; Jie Cao; Shu-nan Wan; Chang-li Du; Wei R. Chen; Yue-qing Gu

doi:10.1117/12.907783

14 February 2012 Synthesis and characterization of NIR light-responsive LbL nanocapsules

Xue-mei Chi, Jie Cao, Shu-nan Wan, Chang-li Du, Wei R. Chen, Yue-qing Gu

Proceedings Volume 8224, Biophotonics and Immune Responses VII; 82240J (2012) https://doi.org/10.1117/12.907783
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

In this paper, near-infrared (NIR) light responsive polyelectrolyte multilayer capsules (PE/Au NRs@Dox) were successfully synthesized by layer-by-layer techniques. Gold nanorods with aspect ratio of 3.9, and a longitudinal absorbance peak at 765nm were prepared using seed-mediated method which used the cationic surfactant cetyltrimethylammonium bromide (CTAB) as a soft template and structure-guiding agent. Sequential layers of polyanions (sodium polystyrene sulfonate (PSS)) and polycations (poly diallyldimethylammonium chloride (PDADMAC)) were followed by adsorption of three BSA/PSS bilayers. The doxorubicin (Dox) is loaded by the electrostatic interaction. The release of Dox from the swelling polyelectrolyte complex PE/Au NRs@Dox was induced by the heat generated from gold nanorods under laser irradiation. Moreover, the in vitro cytotoxicity of PE/Au NRs@Dox and the doxorubicin release from the composites were investigated.

Citation Download Citation

Xue-mei Chi, Jie Cao, Shu-nan Wan, Chang-li Du, Wei R. Chen, and Yue-qing Gu "Synthesis and characterization of NIR light-responsive LbL nanocapsules", Proc. SPIE 8224, Biophotonics and Immune Responses VII, 82240J (14 February 2012); https://doi.org/10.1117/12.907783

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KEYWORDS

Gold

Near infrared

Absorption

Nanorods

In vitro testing

Adsorption

Composites

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