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9 February 2012 A new diagnostic tool based on diffusion reflection measurements of gold nanoparticles
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Abstract
The ability to quantitatively and non-invasively detect nanoparticles in tissues has important implications on their development as an in-vivo cancer diagnostic tool. The Diffusion Reflection (DR) method is a simple, non-invasive imaging technique which has been proven useful for the investigation of tissue's optical parameters. We present a new method for the measurements of the GNR concentration in tissue-like phantoms based on DR measurements and the intense light absorption of gold nanorods (GNR). Monte Carlo simulations and tissue-like phantom measurements of the reflected light intensity are presented. The ability to extract the phantoms' optical properties and the GNR concentration in it from DR measurements was demonstrated.
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Rinat Ankri, Hamootal Duadi, and Dror Fixler "A new diagnostic tool based on diffusion reflection measurements of gold nanoparticles", Proc. SPIE 8225, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues X, 82250L (9 February 2012); https://doi.org/10.1117/12.908789
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