2 February 2012 Analyze fluorescent characteristic of cancer cell using hyperspectroscopic imaging system (HIS)
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Abstract
Currently, the cancer was examined by diagnosing the pathological changes of tumor. If the examination of cancer can diagnose the tumor before the cell occur the pathological changes, the cure rate of cancer will increase. This research develops a human-machine interface for hyper-spectral microscope. The hyper-spectral microscope can scan the specific area of cell and records the data of spectrum and intensity. These data is helpful to diagnose tumor. This study finds the hyper-spectral imaging have two higher intensity points at 550nm and 700nm, and one lower point at 640nm between the two higher points. For analyzing the hyper-spectral imaging, the intensity at the 550nm peak divided by the intensity at 700nm peak. Finally, we determine the accuracy of detection by Gaussian distribution. The accuracy of detecting normal cells achieves 89%, and the accuracy of cancer cells achieves 81%.
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Yao-Fang Hsieh, Yao-Fang Hsieh, Chih-Hsien Chen, Chih-Hsien Chen, Ou-Yang Mang, Ou-Yang Mang, Jeng-Ren Duann, Jeng-Ren Duann, Jin-Chern Chiou, Jin-Chern Chiou, Shun-De Wu, Shun-De Wu, Yong-Jiun Lin, Yong-Jiun Lin, Ming-Hsui Tsai, Ming-Hsui Tsai, Nai-Wen Chang, Nai-Wen Chang, } "Analyze fluorescent characteristic of cancer cell using hyperspectroscopic imaging system (HIS)", Proc. SPIE 8227, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX, 822712 (2 February 2012); doi: 10.1117/12.907930; https://doi.org/10.1117/12.907930
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