2 February 2012 Time-resolved single molecule microscopy coupled with atomic force microscopy
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Abstract
Time-resolved confocal microscopy is well established to image spectral and spatial properties of samples in biology and material science. Atomic Force Microscopy (AFM) in addition enables to investigate properties which are not optically addressable or are hidden by the diffraction limited optical resolution. We present a straight forward combination of single molecule sensitive time-resolved confocal microscopy with different commercially available AFMs. Besides an extra of information about for example a cell surface, the AFM tip can also be used to manipulate the sample on a nanometer scale down to the single molecule level.
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M. König, F. Koberling, O. Schulz, R. Ros, S. Fore, M. Sackrow, S. Trautmann, R. Erdmann, "Time-resolved single molecule microscopy coupled with atomic force microscopy", Proc. SPIE 8227, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX, 822719 (2 February 2012); doi: 10.1117/12.906177; https://doi.org/10.1117/12.906177
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