10 February 2012 Modeling the effect of refraction on OCT imaging of lung tissue: a ray-tracing approach
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Abstract
Determining the structure of lung tissue is difficult in ex-vivo samples. Optical coherence tomography (OCT) can image alveoli but ignores optical effects that distort the images. For example, light refracts and changes speed at the alveolar air-tissue surface. We employ ray-tracing to model OCT imaging with directional and speed changes included, using spherical shapes in 2D. Results show apparent thickening of inter-aveolar walls and distortion of shape and depth. Our approach suggests a correction algorithm by combining the model with image analysis. Distortion correction will allow inference of tissue mechanical properties and deeper imaging.
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Fatemeh N. Golabchi, Ali Golabchi, Dana H. Brooks, Andrew Gouldstone, Charles A. DiMarzio, "Modeling the effect of refraction on OCT imaging of lung tissue: a ray-tracing approach", Proc. SPIE 8227, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX, 82271R (10 February 2012); doi: 10.1117/12.909649; https://doi.org/10.1117/12.909649
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