Possible diffusive reference standards for tissue phantoms based on fat emulsions

Paola Di Ninni; Yves Bérubé-Lauzière; Fabrizio Martelli

doi:10.1117/12.908621

17 February 2012 Possible diffusive reference standards for tissue phantoms based on fat emulsions

Paola Di Ninni, Yves Bérubé-Lauzière, Fabrizio Martelli

Proceedings Volume 8229, Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV; 82290T (2012) https://doi.org/10.1117/12.908621
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

The use of Intralipid 20% was recently suggested as a diusive reference standard for tissue simulating phantoms. We herein extend previously obtained results to other fat emulsions, specically Intralipid 10%, Intralipid 30%, Lipovenoes 10%, Lipovenoes 20%, Lipofundin S 10%, and Lipofundin S 20%. Of particular importance for practical applications, our measurements carried out at a wavelength of 751 nm show the following features. First, batch-to-batch variations of the optical properties of these products are less than 2 % similarly to Intralipid 20%. Second, the absorption coecient of Intralipid, Lipovenoes, and Lipofundin S are very similar and their measured values are within the experimental errors. Third, the reduced scattering of Intralipid 20%, Lipovenoes 20%, and Lipofundin S 20% are similar and their measured values are within 5%. Forth, the reduced scattering coecient of Intralipid 10% and Intralipid 30% can be scaled from that of Intralipid 20% with an error of 9% and 2%, respectively. A similar scaling property is valid for Lipovenoes and Lipofundin S.

Citation Download Citation

Paola Di Ninni, Yves Bérubé-Lauzière, and Fabrizio Martelli "Possible diffusive reference standards for tissue phantoms based on fat emulsions", Proc. SPIE 8229, Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV, 82290T (17 February 2012); https://doi.org/10.1117/12.908621

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