2 February 2012 Three-dimensional calibration targets for optical coherence tomography
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The recent expansion of clinical applications for optical coherence tomography (OCT) is driving the development of approaches for consistent image acquisition. There is a simultaneous need for time-stable, easy-to-use imaging targets for calibration and standardization of OCT devices. We present calibration targets consisting of three-dimensional structures etched into nanoparticle-embedded resin. Spherical iron oxide nanoparticles with a predominant particle diameter of 400 nm were homogeneously dispersed in a two part polyurethane resin and allowed to harden overnight. These samples were then etched using a precision micromachining femtosecond laser with a center wavelength of 1026 nm, 100kHz repetition rate and 450 fs pulse duration. A series of lines in depth were etched, varying the percentage of inscription energy and speed of the translation stage moving the target with respect to the laser. Samples were imaged with a dual wavelength spectral-domain OCT system (λ=800nm, ▵λ≈180nm, and λ=1325nm, ▵λ≈100nm) and point-spread function of nanoparticles within the target was measured.
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Michelle Gabriele Sandrian, Michelle Gabriele Sandrian, Pete Tomlins, Pete Tomlins, Peter Woolliams, Peter Woolliams, Janarthanan Rasakanthan, Janarthanan Rasakanthan, Graham CB Lee, Graham CB Lee, Anna Yang, Anna Yang, Boris Považay, Boris Považay, Aneesh Alex, Aneesh Alex, Kate Sugden, Kate Sugden, Wolfgang Drexler, Wolfgang Drexler, } "Three-dimensional calibration targets for optical coherence tomography", Proc. SPIE 8229, Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV, 822914 (2 February 2012); doi: 10.1117/12.907748; https://doi.org/10.1117/12.907748

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