2 February 2012 Study of specificity for noninvasive glucose measurements based on two-dimensional correlation mid-infrared spectroscopy
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Abstract
Glucose specificity is the premise of spectroscopic measurements for blood glucose concentration, and it is also paramount for feasibility study of a spectral measurement method. Two-dimensional correlation spectroscopy technology is widely used in many fields such as inter-/intra-molecular reaction, material phase transition and information extraction because of its high resolution and the effective "sequential order" rules (Noda's rule). By using 2D correlation spectroscopy analysis, we aim at exploring glucose specificity for noninvasive glucose measurements from mid-infrared spectra collected from human beings. The study is mainly divided into two parts. The first part is to prove the realizability of the method by 2D correlation analysis of in vitro solutions which all contain glucose. And the second part is validating characteristic information of glucose from mid-infrared ATR spectra of human fingers by use of the 2D correlation spectroscopy technology. The conclusion is that glucose specific spectral information is really present in noninvasive mid-infrared in vivo spectra. So the feasibility of mid-infrared spectroscopy in noninvasive measurements of blood glucose concentration is demonstrated fundamentally.
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Yuzhen Cao, Yuzhen Cao, Wen Zhang, Wen Zhang, Rong Liu, Rong Liu, Wanjie Zhang, Wanjie Zhang, Kexin Xu, Kexin Xu, } "Study of specificity for noninvasive glucose measurements based on two-dimensional correlation mid-infrared spectroscopy", Proc. SPIE 8229, Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV, 82291B (2 February 2012); doi: 10.1117/12.907858; https://doi.org/10.1117/12.907858
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