Effect on glucose monitoring of pressure exerted by fiber-optic probe: skin model and simulation

Chenxi Li; Huijuan Zhao; Zhenzhi Shi; Kexin Xu

doi:10.1117/12.907340

2 February 2012 Effect on glucose monitoring of pressure exerted by fiber-optic probe: skin model and simulation

Chenxi Li, Huijuan Zhao, Zhenzhi Shi, Kexin Xu

Proceedings Volume 8229, Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV; 82291H (2012) https://doi.org/10.1117/12.907340
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

In the research of optical diagnosis, such as noninvasive measurement of blood glucose by near-infrared diffuse-reflectance spectroscopy, the fiber-optic probe are widely used to deliver light to the interested tissue site and collect the light from the tissue. In order to minimize motion artifacts and specula reflectance, the fiber-optic probe contact to tissue site with certain pressure. The spacing between tissue components decreased due to water displacement, while the volumes of cells and elastic fibers are reduced which in turn increase the concentration of the scatter and absorber inside the tissue. In our research a three-layer skin model is established and the Finite Element Method is employed to simulate the deformation of skin tissue caused by fiber-optic probe with different pressure. The change of water volume inside the tissue as well as the concentration and scattering cross section of scatters are considered. The Monte Carlo simulation is utilized to establish the diffuse-reflectance spectroscopy of three-layer skin model before and after compression. The result indicated that the pressure of fiber-optics probe should be controlled less the 50kpa to reduce the influence on measurement.

Citation Download Citation

Chenxi Li, Huijuan Zhao, Zhenzhi Shi, and Kexin Xu "Effect on glucose monitoring of pressure exerted by fiber-optic probe: skin model and simulation", Proc. SPIE 8229, Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV, 82291H (2 February 2012); https://doi.org/10.1117/12.907340

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