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2 February 2012 Influence of air bubbles on the recovery of optical properties
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In some vital organs of the human body the air bubbles are indicative of the presence of disease. On the other hand, poor information has been published considering the effect of air bubbles on the optical properties of tissue mimicking phantoms. The goal of this study was to investigate the influence of air bubbles on the optical properties of polyurethane phantoms. A two-integrating spheres system (TISS) in combination with the IAD method was used to determine the optical properties of a set of polyurethane phantoms fabricated with different levels of air bubbles. Phantoms were characterized with a microscope and a fiber optic spectrometer using a two-fiber probe. Results indicate that the TISS in conjunction with the IAD method is insensitive to the level of air bubbles within polyurethane phantoms whereas that for the spectrometric system a noticeable difference was found for the spectra of phantoms prepared with different levels of air bubbles. A change of reflectance spectra above 25 % at 428 nm was found when degassing sample time changed from 5 to 10 minutes. This finding indicates that controlling the degassing step of phantoms is more critical when they are required for the validation and standardization of devices that have a robust working principle based on the probing of a localized volume such as it is the case of fiber optic probes.
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Jose Alberto Delgado Atencio, Beatriz Morales Cruzado, and Sergio Vázquez y Montiel "Influence of air bubbles on the recovery of optical properties", Proc. SPIE 8229, Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV, 82291K (2 February 2012);

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