Translator Disclaimer
2 February 2012 Effects of La0.2Ce0.6Eu0.2F3 nanoparticles capped with polyethylene glycol on human astrocytoma cells in vitro
Author Affiliations +
Abstract
Lanthanide fluoride colloidal nanocrystals offer a way to improve the diagnosis and treatment of cancer through the enhanced absorption of ionizing radiation, as well as providing visible luminescence. In order to explore this possibility, cytotoxicity assays need to be performed on mammalian cells in vitro, to show minimum levels of biocompatibility for future experiments. 20% lanthanum 60% cerium and 20% europium lanthanide fluoride nanocrystals were capped with polyethylene glycol (PEG) of molecular weight 4000 and suspended in deionized water. These nanocrystals were characterized by transmission electron microscopy, muffle furnace ashing, absorbance spectroscopy, dynamic light scattering, and photoluminescence spectroscopy. Visible light microscopy and trypan blue staining was performed on the cells to assay the cytotoxicity of the nanocrystal on the human astrocytoma line U-87 MG, purchased from ATCC.
© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Nathan J. Withers, Yekaterina Brandt, Antonio C. Rivera, Leisha M. Armijo, Nathaniel C. Cook, and Marek Osiński "Effects of La0.2Ce0.6Eu0.2F3 nanoparticles capped with polyethylene glycol on human astrocytoma cells in vitro", Proc. SPIE 8232, Colloidal Nanocrystals for Biomedical Applications VII, 82320R (2 February 2012); https://doi.org/10.1117/12.911953
PROCEEDINGS
9 PAGES


SHARE
Advertisement
Advertisement
Back to Top