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24 February 2012 Plant virus-resembling optical nano-materials conjugated with anti-EGFR for targeted cancer imaging
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Abstract
We recently reported the construction of a new type of optically active nano-particles composed of genome-depleted plant infecting brome mosaic virus (BMV) doped with indocyanine green (ICG), an FDA-approved chromophore . We refer to these constructs as optical viral ghosts (OVGs) since only the capsid protein (CP) subunits of BMV remain to encapsulate ICG. Herein, we covalently conjugated the surface of OVGs with anti-epidermal growth factor receptors (anti-EGFR) to target cancerous human bronchial epithelial cells (C-HBECs) in-vitro. Our preliminary results demonstrate the utility of conjugated OVGs for targeted imaging of cancer cells.
© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Sharad Gupta, Hailey Wilder, A. L. N. Rao, V. I. Vullev, and Bahman Anvari "Plant virus-resembling optical nano-materials conjugated with anti-EGFR for targeted cancer imaging", Proc. SPIE 8233, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV, 82330S (24 February 2012); https://doi.org/10.1117/12.907730
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