Dual modality photothermal OCT and magnetic resonance imaging with carbon nanotubes

Jason M. Tucker-Schwartz; Tu Hong; Daniel C. Colvin; Yaqiong Xu; Melissa C. Skala

doi:10.1117/12.914055

2 February 2012 Dual modality photothermal OCT and magnetic resonance imaging with carbon nanotubes

Jason M. Tucker-Schwartz, Tu Hong, Daniel C. Colvin, Yaqiong Xu, Melissa C. Skala

Proceedings Volume 8233, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV; 823310 (2012) https://doi.org/10.1117/12.914055
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Preclinical molecular imaging of cancer has the potential to increase the understanding of fundamental cancer biology, elucidate mechanisms of cancer treatment resistance, and increase effectiveness of drug candidates. Optical and magnetic resonance imaging contain complementary strengths, suitable for gaining a wealth of knowledge when combined. Here, we demonstrate the inherent contrast sensitivity of single walled carbon nanotubes to absorption based photothermal optical coherence tomography (PT-OCT), and magnetic resonance imaging spin dephasing contrast (T₂). A spectral-domain OCT system was interfaced with an amplitude-modulated (100 Hz) titanium sapphire pump beam for PT-OCT imaging. MRI was performed with a commercial 4.7 T animal scanner. With both imaging tools, contrast agent signal linearity (r² > 0.95) and nM sensitivity over background (p < 0.05) was experimentally determined with serially dilute solutions of carbon nanotubes coated in amine-terminated polyethylene glycol. The surface functionalization chemistry for carbon nanotubes is well understood, and molecular targeting has been demonstrated in vitro and in vivo, making carbon nanotubes an attractive agent for molecular imaging in preclinical models. We have demonstrated the initial characterization steps for using carbon nanotubes for multi-modality imaging with PT-OCT and MRI.

Citation Download Citation

Jason M. Tucker-Schwartz, Tu Hong, Daniel C. Colvin, Yaqiong Xu, and Melissa C. Skala "Dual modality photothermal OCT and magnetic resonance imaging with carbon nanotubes", Proc. SPIE 8233, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV, 823310 (2 February 2012); https://doi.org/10.1117/12.914055

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KEYWORDS

Magnetic resonance imaging

Optical coherence tomography

Carbon nanotubes

Capillaries

Molecular imaging

Image resolution

Solids

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