2 February 2012 Dual modality photothermal OCT and magnetic resonance imaging with carbon nanotubes
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Preclinical molecular imaging of cancer has the potential to increase the understanding of fundamental cancer biology, elucidate mechanisms of cancer treatment resistance, and increase effectiveness of drug candidates. Optical and magnetic resonance imaging contain complementary strengths, suitable for gaining a wealth of knowledge when combined. Here, we demonstrate the inherent contrast sensitivity of single walled carbon nanotubes to absorption based photothermal optical coherence tomography (PT-OCT), and magnetic resonance imaging spin dephasing contrast (T2). A spectral-domain OCT system was interfaced with an amplitude-modulated (100 Hz) titanium sapphire pump beam for PT-OCT imaging. MRI was performed with a commercial 4.7 T animal scanner. With both imaging tools, contrast agent signal linearity (r2 > 0.95) and nM sensitivity over background (p < 0.05) was experimentally determined with serially dilute solutions of carbon nanotubes coated in amine-terminated polyethylene glycol. The surface functionalization chemistry for carbon nanotubes is well understood, and molecular targeting has been demonstrated in vitro and in vivo, making carbon nanotubes an attractive agent for molecular imaging in preclinical models. We have demonstrated the initial characterization steps for using carbon nanotubes for multi-modality imaging with PT-OCT and MRI.
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Jason M. Tucker-Schwartz, Jason M. Tucker-Schwartz, Tu Hong, Tu Hong, Daniel C. Colvin, Daniel C. Colvin, Yaqiong Xu, Yaqiong Xu, Melissa C. Skala, Melissa C. Skala, } "Dual modality photothermal OCT and magnetic resonance imaging with carbon nanotubes", Proc. SPIE 8233, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV, 823310 (2 February 2012); doi: 10.1117/12.914055; https://doi.org/10.1117/12.914055

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