2 February 2012 Highly efficient phosphors in cancer sensing and PDT
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Highly efficient upconverting phosphors (NaYF4) doped with erbium ions are bio-conjugated and used for cancer imaging and photodynamic therapy. Once they are conjugated, the particles are injected into mice to demonstrate that cancer imaging with a near-infrared excitation source is possible. Finally, the particles are also conjugated with a photosensitive molecule with strong absorption near the upconversion emission peak (~ 550nm). The upconversion energy causes the photosensitive molecule to create highly reactive oxidative species, which puncture and kill the cell to which it is attached. These particles are then used in a mouse model, and the size of the tumors is modeled as a function of the dosage and duration of the photodynamic therapy.
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Brian G. Yust, Lawrence C. Mimun, Dhiraj K. Sardar, Gangadharan Ajith Kumar, Peter J. Hornsby, Jason Rocha, "Highly efficient phosphors in cancer sensing and PDT", Proc. SPIE 8233, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV, 823312 (2 February 2012); doi: 10.1117/12.908986; https://doi.org/10.1117/12.908986

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