A magnetic-field enriched surface-enhanced resonance Raman spectroscopy strategy towards the early diagnosis of malaria

Clement Yuen; Quan Liu

doi:10.1117/12.906334

6 February 2012 A magnetic-field enriched surface-enhanced resonance Raman spectroscopy strategy towards the early diagnosis of malaria

Clement Yuen, Quan Liu

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Proceedings Volume 8234, Plasmonics in Biology and Medicine IX; 82340H (2012) https://doi.org/10.1117/12.906334
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Early malaria diagnosis is important because malaria disease can develop into fatal illness within hours upon the appearance of the first symptom. The low concentration of the diagnosis biomarker, hemozoin, at the early stage of malaria disease makes early diagnosis difficult. In this paper, we present a magnetic field-enriched surface-enhanced resonance Raman spectroscopy (SERRS) strategy for the sensitive detection of β - hematin crystals, which is equivalent to hemozoin in the characteristics of Raman spectrum, by using magnetic nanoparticles. We observe several orders of magnitude enhancement in the SERRS signal of enriched β - hematin in comparison to the Raman signal of β - hematin in the cases of SERRS alone or magnetic enrichment alone, showing the great potential of this method towards early malaria diagnosis.

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Clement Yuen and Quan Liu "A magnetic-field enriched surface-enhanced resonance Raman spectroscopy strategy towards the early diagnosis of malaria", Proc. SPIE 8234, Plasmonics in Biology and Medicine IX, 82340H (6 February 2012); https://doi.org/10.1117/12.906334

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KEYWORDS

Nanoparticles

Raman spectroscopy

Magnetism

Crystals

Bioalcohols

Silver

Electron microscopes

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