6 February 2012 Characterization of individual microdroplets by SERRS spectroscopy
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Proceedings Volume 8234, Plasmonics in Biology and Medicine IX; 82340I (2012) https://doi.org/10.1117/12.906374
Event: SPIE BiOS, 2012, San Francisco, California, United States
Abstract
Raman spectroscopy and its various derivatives continue to offer the analyst fast, powerful, non-invasive and nondestructive means by which to identify multiple analytes simultaneously and in real time. By virtue of the huge enhancements possible in Raman scattering, generated by both surface enhancement and the resonance Raman effect, or when coupled with other techniques such as confocal microscopy, Raman spectroscopy is becoming more and more applicable to the types of assay being conducted in lab-on-a-chip applications, such as flow cytometry, cell patterning and trapping, and microarrays, all of which often involve the detection of extremely low quantities of analyte. Surface enhanced Raman scattering (SERS, or when coupled with the resonance Raman phenomenon, SERRS) spectroscopy has proven to be of particular use as a robust optical detection method in microfluidic environments. In this paper, we demonstrate the use of SERRS multiplex detection to quantitatively characterize individual microdroplets in a continuous stream whose contents are gradually varied using a bespoke pump control algorithm.
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Christopher D. Syme, Narayana Sirimuthu, Chiara Martino, Rama Yusvana, Jonathan M. Cooper, "Characterization of individual microdroplets by SERRS spectroscopy", Proc. SPIE 8234, Plasmonics in Biology and Medicine IX, 82340I (6 February 2012); doi: 10.1117/12.906374; https://doi.org/10.1117/12.906374
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