6 February 2012 Multifunctional gold nanorods for image-guided surgery and photothermal therapy
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Proceedings Volume 8234, Plasmonics in Biology and Medicine IX; 82340Z (2012) https://doi.org/10.1117/12.908253
Event: SPIE BiOS, 2012, San Francisco, California, United States
Abstract
Nanoparticles are viewed as a promising tool for numerous medical applications, for instance imaging and photothermal therapy (PTT) has been proposed using gold nanorods. We are developing multi-functional gold nanorods (m-GNRs) which have potential for image guided endoscopic surgery of tumour tissue with a modified laparoscope system. A new synthesis method potentially allows any useful acid functionalised molecules to be bonded at the surface. We have created fluorescent m-GNRs which can be used for therapy as they absorb light in the infrared, which may penetrate deep into the tissue and produce localised heating. We have performed a tissue based experiment to demonstrate the feasibility of fluorescence guided PTT using m- GNRs. Ex vivo tests were performed using sheep heart. This measurement, correlated with the fluorescence signal of the m-GNRs measured by the laparoscope allows the clear discrimination of the artery system containing m-GNRs. A laser diode was used to heat the m-GNRs and a thermal camera was able to record the heat distribution. These images were compared to the fluorescence images for validation.
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Clement Barriere, Clement Barriere, Ji Qi, Ji Qi, P. Beatriz Garcia-Allende, P. Beatriz Garcia-Allende, Richard Newton, Richard Newton, Daniel S. Elson, Daniel S. Elson, } "Multifunctional gold nanorods for image-guided surgery and photothermal therapy", Proc. SPIE 8234, Plasmonics in Biology and Medicine IX, 82340Z (6 February 2012); doi: 10.1117/12.908253; https://doi.org/10.1117/12.908253
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