17 February 2012 Integration of a three-dimensional filter in a microfluidic chip for separation of microscale particles
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Abstract
We report on the integration of a size-based three-dimensional filter, with micrometer-sized pores, in a commercial microfluidic chip. The filter is fabricated inside an already sealed microfluidic channel using the unique capabilities of two-photon polymerization. This direct-write technique enables integration of the filter by post-processing in a chip that has been fabricated by standard technologies. The filter is located at the intersection of two channels in order to control the amount of flow passing through the filter. Tests with a suspension of 3-ìm polystyrene spheres in a Rhodamine 6G solution show that 100% of the spheres are stopped, while the fluorescent molecules are transmitted through the filter. We demonstrate operation up to a period of 25 minutes without any evidence of clogging. Moreover, the filter can be cleaned and reused by reversing the flow.
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Nicola Bellini, Yu Gu, Lorenzo Amato, Shane Eaton, Giulio Cerullo, Roberto Osellame, "Integration of a three-dimensional filter in a microfluidic chip for separation of microscale particles", Proc. SPIE 8244, Laser-based Micro- and Nanopackaging and Assembly VI, 82440G (17 February 2012); doi: 10.1117/12.908455; https://doi.org/10.1117/12.908455
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