11 February 2012 Bio optofluidics cell sorter: cell-BOCS concept and applications
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Proceedings Volume 8274, Complex Light and Optical Forces VI; 82740J (2012); doi: 10.1117/12.909783
Event: SPIE OPTO, 2012, San Francisco, California, United States
Abstract
The cell-BOCS is a novel microfluidics based cell-sorting instrument utilizing next generation optical trapping technology developed at the Technical University of Denmark. It is targeted emerging bio-medical research and diagnostics markets where it for certain applications offers a number of advantages over conventional fluorescence activated cell-sorting (FACSTM) technology. Advantages include gentle handling of cells, sterile sorting, easy operation, small footprint and lower cost allowing out-of-core-facility use. Application examples are found within sorting of fragile transfected cells, high value samples and primary cell lines, where traditional FACS technology has limited application due to it's droplet-based approach to cell-sorting. In the diagnostics field, in particular applying the cell-BOCS for isolating pure populations of circulating tumor cells is an area that has generated a lot of interest.
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Tue Roth, Jesper Glückstad, "Bio optofluidics cell sorter: cell-BOCS concept and applications", Proc. SPIE 8274, Complex Light and Optical Forces VI, 82740J (11 February 2012); doi: 10.1117/12.909783; https://doi.org/10.1117/12.909783
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KEYWORDS
Microfluidics

Diagnostics

Blood

Analytical research

Luminescence

Tumors

Optical tweezers

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